Pharmacological Modulation of Oxidative Stress

Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects

Notwithstanding the fact that the multiple roles of oxidative stress in human biology and pathology have been intensely discussed over the last half century, the problem is still far beyond our full comprehension. Thus, in a comparatively short history of oxidative medicine, the roles of two major heroes, free radicals and antioxidants, have been entirely redefined. Free radicals and other reac...

Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects 2017

Pharmacological modulation of oxidative stress response in minimally invasive surgery: systematic review.

This systematic review aims to synthesize the data on the effectiveness of pharmacological modulation of stress response in minimally invasive surgery. Eligible trials were clinical trials randomized or not or experimental trials that investigated the effect of pharmacological agents on modulation of surgical stress response to minimally invasive surgery. No clinical trials were identified. Eig...

Potential Modulation of Sirtuins by Oxidative Stress

Sirtuins are a conserved family of NAD-dependent protein deacylases. Initially proposed as histone deacetylases, it is now known that they act on a variety of proteins including transcription factors and metabolic enzymes, having a key role in the regulation of cellular homeostasis. Seven isoforms are identified in mammals (SIRT1-7), all of them sharing a conserved catalytic core and showing di...

Modulation of Oxidative Stress by Twist Oncoproteins

Expression of developmental genes Twist1 and Twist2 is reactivated in many human tumors. Among their oncogenic activities, induction of epithelial to mesenchymal transition is believed to increase cell motility and invasiveness and may be related to acquisition of cancer stem cell phenotype. In addition, Twist proteins promote malignant conversion by overriding two oncogene-induced failsafe pro...